Indian J Sex Transm Dis Indian J Sex Transm Dis
Official Publication of the Indian Association for the Study of Sexually Transmitted Diseases
Indian J Sex Transm Dis
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Year : 2008  |  Volume : 29  |  Issue : 2  |  Page : 96-97

Leprosy presenting as immune reconstitution Inflammatory Syndrome

Dept of Dermatology, Civil Hospital and BJ Medical College, Asarwa, Ahmedabad, India

Correspondence Address:
Sujata Mehta
'Sumeru', St. Xavier's College Corner, Navrangpura, Ahmedabad
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0253-7184.48734

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A 35-year-old HIV-reactive female presented to us with multiple erythematous plaques on her face, trunk, and limbs, since five days. Bilateral ulnar and lateral popliteal nerves were thickened and tender. ­Antiretroviral drugs (d4T, 3TC, NVP) had been started one month prior. Slit skin smear was negative. Skin biopsy from infiltrated lesions showed ill-defined, noncaseating epitheloid granulomas, confirming the diagnosis of ­borderline tuberculoid leprosy, with reversal reaction. In the setting of the recent Antiretroviral Therapy (ART) this is considered clinically as Immune Reconstitution Inflammatory Syndrome (IRIS).

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