Indian J Sex Transm Dis Indian J Sex Transm Dis
Official Publication of the Indian Association for the Study of Sexually Transmitted Diseases
Indian J Sex Transm Dis
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Year : 2010  |  Volume : 31  |  Issue : 2  |  Page : 109-111

Unusual cause of weight loss in a patient with HIV-hepatitis C virus coinfection

Department of Medicine, Sir Ganga Ram Hospital, Rajinder Nagar, New Delhi - 110 060, India

Correspondence Address:
A Gogia
J-6/27, Rajouri Garden, New Delhi - 110 027
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0253-7184.75004

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Recombinant interferon α (IFN α), alone or in combination, is used extensively in the treatment of hepatitis C infection. IFN therapy is not free of side-effects and autoimmune thyroiditis is one of its rare side-effects. We present here a case of a patient with hepatitis C virus-human immunodeficiency virus coinfection on interferon therapy who presented with significant weight loss. He was found to have IFN-related autoimmune thyrotoxicosis and responded to antithyroid drugs and propanolol. Therefore, this case highlights that IFN-induced thyroiditis is an unusual side-effect and that during treatment, a thyroid-stimulating hormone assay should be performed at regular intervals (every 8-12 weeks).

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