Indian J Sex Transm Dis Indian J Sex Transm Dis
Official Publication of the Indian Association for the Study of Sexually Transmitted Diseases
Indian J Sex Transm Dis
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Year : 2011  |  Volume : 32  |  Issue : 2  |  Page : 114-117

Penile pyoderma gangrenosum successfully treated with topical Imiquimod

Deparment of Skin and V.D., B.J. Medical College, Civil Hospital, Ahmedabad, Gujarat, India

Correspondence Address:
Santosh P Rathod
Deparment of Skin and V.D, Room No. 139, skin O.P.D., 1st floor, 3rdWing, Civil hospital, Ahmedabad - 380016, Gujarat
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0253-7184.85418

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Pyoderma gangrenosum(PG) is a rare ulcerating inflammatory neutrophilic dermatosis. Genital involvement has been rarely reported. We report such a case of 24- year- old, male patient living with HIV/AIDS(PLHIV) who presented with progressive genital ulceration, not responding to oral antibiotics and aciclovir, gradually increasing in size over 15-18 months. Repeated biopsies showed acute on chronic inflammation. The lesion partially responded to oral and topical corticosteroids but soon increased in size after tapering the dosage of the steroids.Then patient was given Imiquimod 5% cream to be applied over the lesion once daily for 2-4 weeks. Lesion cleared completely in 4 weeks and is in remission since last 6 months. The case report highlights the successful use of topical Imiquimod 5% cream in the treatment of penile PG.

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