Indian J Sex Transm Dis Indian J Sex Transm Dis
Official Publication of the Indian Association for the Study of Sexually Transmitted Diseases
Indian J Sex Transm Dis
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CASE REPORT
Year : 2022  |  Volume : 43  |  Issue : 2  |  Page : 183-185

Prozone phenomenon in secondary syphilis with HIV co-infection: Two cases


1 Department of Dermatology, Venereology and Leprosy, Symbiosis Medical College for Women, Symbiosis International University, Pune, Maharashtra, India
2 Department of Microbiology, Symbiosis Medical College for Women, Symbiosis International University, Pune, Maharashtra, India

Correspondence Address:
Dr. Praneet Awake
Department of Dermatology, Venereology and Leprosy, Symbiosis Medical College for Women, Symbiosis International University, Lavale, Mulshi, Pune - 412 115, Maharashtra
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ijstd.ijstd_43_22

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Prozone phenomenon is defined as a false-negative response resulting from higher antibody titer which interferes with formation of antigen–antibody lattice, necessary to visualize a positive flocculation test. The prozone effect can be observed in syphilis testing with cases of very high antibody titers, such as secondary syphilis, or with human immunodeficiency virus (HIV) co-infection. We report two cases of prozone phenomenon in secondary syphilis with HIV co-infection who initially tested nonreactive for rapid plasma reagin test but tested positive with further higher dilution.


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