| CASE REPORT |
|
| Year : 2022 | Volume
: 43
| Issue : 2 | Page : 183-185 |
|
|
Prozone phenomenon in secondary syphilis with HIV co-infection: Two cases
Praneet Awake1, Kalpana Angadi2, Sourav Sen2, Prasad Bhadange1
1 Department of Dermatology, Venereology and Leprosy, Symbiosis Medical College for Women, Symbiosis International University, Pune, Maharashtra, India
2 Department of Microbiology, Symbiosis Medical College for Women, Symbiosis International University, Pune, Maharashtra, India
Correspondence Address:
Dr. Praneet Awake
Department of Dermatology, Venereology and Leprosy, Symbiosis Medical College for Women, Symbiosis International University, Lavale, Mulshi, Pune - 412 115, Maharashtra
India
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/ijstd.ijstd_43_22
|
|
|
Prozone phenomenon is defined as a false-negative response resulting from higher antibody titer which interferes with formation of antigen–antibody lattice, necessary to visualize a positive flocculation test. The prozone effect can be observed in syphilis testing with cases of very high antibody titers, such as secondary syphilis, or with human immunodeficiency virus (HIV) co-infection. We report two cases of prozone phenomenon in secondary syphilis with HIV co-infection who initially tested nonreactive for rapid plasma reagin test but tested positive with further higher dilution.
|
|
|
|
| [FULL TEXT] [PDF]* |
|
 |
|
