Indian J Sex Transm Dis Indian J Sex Transm Dis
Official Publication of the Indian Association for the Study of Sexually Transmitted Diseases
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CASE REPORT
Year : 2022  |  Volume : 43  |  Issue : 2  |  Page : 203-205

Disseminated histoplasmosis as a presenting manifestation in an HIV patient – A case report from South India


1 Department of Dermatology, Jawaharlal Institute of Postgraduate Medical Education and Research, Kalapet, Puducherry, India
2 Department of Dermatology, Pondicherry Institute of Medical Sciences, Kalapet, Puducherry, India
3 Department of Pathology, Jawaharlal Institute of Postgraduate Medical Education and Research, Kalapet, Puducherry, India

Correspondence Address:
Dr. Remya Raj Rajamohanan
Department of Dermatology, Pondicherry Institute of Medical Sciences, Kalapet, Puducherry - 605 014
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ijstd.ijstd_45_21

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Histoplasmosis has heterogenous clinical presentation ranging from mild and self-limiting respiratory disease to disseminated forms with high mortality. In progressive disseminated histoplasmosis (PDH), patient presents with fever, lymphadenopathy, hepatosplenomegaly, adrenal enlargement, hemophagocytic lymphohistiocytosis and non-specific mucocutaneous lesions, usually in late stage of HIV. Cutaneous involvement is upto 25% in PDH which are papules, plaques, nodules and ulcers. Forty-two year old male, recently diagnosed as HIV positive presented with complaints of multiple painful ulcerated lesions over face, neck, tongue, arms, trunk & genitalia. Skin Biopsy was suggestive of histoplasmosis. Patient showed excellent response with amphotericin B and itraconazole. Since histoplasmosis is relatively uncommon, there should be a high-index of suspicion when an HIV patient presents with disseminated skin lesions.


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