Indian J Sex Transm Dis Indian J Sex Transm Dis
Official Publication of the Indian Association for the Study of Sexually Transmitted Diseases
Indian J Sex Transm Dis
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Year : 2023  |  Volume : 44  |  Issue : 1  |  Page : 30-34

Study of serum level of kisspeptin and interferon-beta in genital wart patients

1 Department of Dermatology and Andrology, Faculty of Medicine, Menoufia University, Shebin El-Kom, Egypt
2 Department of Molecular Diagnostics and Therapeutics, Genetic Engineering and Biotechnology Research Institute, Sadat City, Egypt
3 Department of Clinical Pathology, Medical Research Division, National Research Centre, Cairo, Egypt
4 Department of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Menoufia University, Shebin El-Kom, Egypt

Correspondence Address:
Dr. Heba Allah Saad Eldeen Bazid
93 Misr Wa Elsudan Street, Cairo
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/ijstd.ijstd_93_22

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Background: Researchers are interested in genital wart (GW) studies due to their increased incidence. In a single experimental research, virally infected mouse models showed elevated kisspeptin levels and low interferon levels. Objective: The objective of the study was to evaluate the serum levels of kisspeptin and interferon (INF)-beta in GW patients. Patients and Methods: Forty patients with GWs and forty healthy participants of comparable age and sex as a control group were included in this case–control study. Serum levels of kisspeptin and IFN-beta were measured using ELISA during the period from December 2021 to April 2022. Results: Kisspeptin was significantly higher among cases than controls, whereas IFN-beta level was lower among cases than controls (P < 0.001). There were no significant relations between kisspeptin and IFN-beta levels and the clinical data for the studied participants, and there was no significant correlation between both (P > 0.05). Conclusion: The reported increased kisspeptin level which was associated with decreased interferon-beta level in patients with GWs might indicate a new insight into viral infection pathogenesis. Further research including all steps in kisspeptin/G protein-coupled receptor 54 pathway is required. Targeted therapy for this pathway may be of value for those patients.

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