Indian Journal of Sexually Transmitted Diseases and AIDS
ORIGINAL ARTICLE
Year
: 2010  |  Volume : 31  |  Issue : 2  |  Page : 99--103

Plasma folate studies in HIV-positive patients at the Lagos university teaching hospital, Nigeria


Akanmu Alani1, Osunkalu Vincent1, Adediran Adewumi1, Adeyemo Titilope1, Ernest Onogu1, Akinde Ralph2, Coker Hab3 
1 Department of Haematology and Blood Transfusion, College of Medicine, University of Lagos, Surulere, Lagos, Nigeria
2 Department of Morbid Anatomy, College of Medicine, University of Lagos, Surulere, Lagos, Nigeria
3 Department of Pharmaceutical Chemistry, College of Medicine, University of Lagos, Surulere, Lagos, Nigeria

Correspondence Address:
Osunkalu Vincent
Department of Haematology and Blood Transfusion, College of Medicine, University of Lagos, PMB 12003, Surulere, Lagos
Nigeria

Introduction: In various studies globally, the prevalence of anemia in persons with HIV infection range from 10 to 20% at initial presentation, and anemia is diagnosed in 70 to 80% of these patients over the course of HIV disease. The etiology of anemia in this group of patients has not been fully established, thus a need to evaluate the role of plasma folate as a possible etiological factor. Objective: This study was set to determine plasma folate levels in newly diagnosed, treatment na´ve, HIV-positive patients, and relate this to other hematological changes. Materials and Methods: A total of 200 participants were recruited for this study, of which 100 were HIV positive, treatment naive patients who were recruited at the point of registration and 100 were HIV-negative subjects (controls). 5 ml of venous blood was collected and plasma extracted for folic acid estimation by HPLC. A full blood count, CD4 and Viral load were estimated. Results: Mean ages for control and study group were 38 ± 2.3 and 32 ± 1.7 years, respectively. Mean plasma folate concentration among the study group (5.04 μg/l) was significantly lower than that for the control group (15.89 μg/l; P = 0.0002). Prevalence of anemia among the study group was 72% (144 of 200), with a mean hemoglobin (Hb) concentration of 9.5 g/dl compared with mean Hb of 13.0 g/dl among the control group (P = 0.002). Plasma folate correlated positively with CD4 cell count (r = 0.304, P<0.05) and inversely with the viral load (r = -0.566; P<0.05). Conclusion: Plasma folate level is a predictor of anemia in early HIV infections.


How to cite this article:
Alani A, Vincent O, Adewumi A, Titilope A, Onogu E, Ralph A, Hab C. Plasma folate studies in HIV-positive patients at the Lagos university teaching hospital, Nigeria.Indian J Sex Transm Dis 2010;31:99-103


How to cite this URL:
Alani A, Vincent O, Adewumi A, Titilope A, Onogu E, Ralph A, Hab C. Plasma folate studies in HIV-positive patients at the Lagos university teaching hospital, Nigeria. Indian J Sex Transm Dis [serial online] 2010 [cited 2022 Jul 6 ];31:99-103
Available from: https://www.ijstd.org/article.asp?issn=2589-0557;year=2010;volume=31;issue=2;spage=99;epage=103;aulast=Alani;type=0